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Desensitization of G-protein-coupled receptors (GPCR) is a general regulatory mechanism adopted by biological organisms against overstimulation of G protein signaling

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Duchenne muscular dystrophy (DMD) is a genetic muscular disease and is the most common type of muscular dystrophy in Japan
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Engineering the decalin configurations would be useful not only to find derivatives with better biological activities but also to discover overlooked biological activities.
