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Acknowledgements The research was supported in part by National Institute of Health (R01-GM115622 and R01-CA250503 to J.W.), NMR and Drug Metabolism Core Facility Support Award from the Cancer Prevention Research Institute of Texas (RP160805), Protein and Monoclonal Antibody Production Core (P30 Cancer Center Support Grant NCI-CA125123), Baylor College of Medicine (seed funding to J.W.) and Howard Hughes Medical Institute (to M.C.W.)