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In this classic signaling pathway, ligand-activated ER dissociates from its chaperone heat-shock protein and binds as a dimer either directly to an estrogen response element (ERE) in target gene promoters or indirectly to activator protein 1 or specificity protein 1 response elements through protein tethering to DNA (13)

Healthcare providers should educate patients about both the therapeutic benefits and potential adverse effects before initiating treatment

Bowel preparations for capsule endoscopy: a comparison between simethicone and magnesium citrate

Similarly, a study assessing the impact of early exposure to prenatal T in sheep between gestational days 2065 did not note any difference in weight trajectory in testes intact and orchiectomized twins 40

Further investigations are needed to examine how modifications by acrolein modulate the function of proteins and cellular processes

Oxygen and reactive oxygen species in cartilage degradation: friends or foes