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e814 Lee J, Ramos E, Lee J et al (2012) CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion

In the case of GSAO, a reversible renal toxicity described in preclinical studies at the maximal tolerated dose was not observed in human during clinical Phase I (Horsley et al., 2013)

Progesterone receptor membrane component 1 modulates human cytochrome P450 activities in an isoform-dependent manner

The result tempers claims that DSIP functions as a cortisol-lowering 'anti-stress' peptide in humans and underscores how limited and inconsistent the controlled human endocrine data for DSIP remain

Emerging human data, including small pilot studies showing good tolerability (e.g., intravenous infusions up to 20 mg with no adverse effects) and subjective improvements in conditions like chronic knee pain, further support its promise

Ethical Committee Approval and Consent to Participate All experimental procedures and research activities related to this study were conducted in accordance with institutional and national guidelines