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For instance, GnRH from the hypothalamus stimulates pituitary secretion of LH and FSH, which act upon the ovaries and testes

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TABLE 2 Ongoing clinical trials for novel non-VEGF/VEGFR angiogenesis inhibitors in breast cancer (retrieved from: www.clinicaltrials.gov)

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Though injection of BOTOX in experienced hands is very accurate, inadvertent weakness can occur

This is due to a favorable electrostatic attraction that induces tight junction opening, resulting in enhanced paracellular transport of ions, macromolecules, and hydrophilic drugs across cell barriers, and importantly, improves the BBB penetration of drug-loaded nanoparticles via adsorptive-mediated endocytosis (Roney et al., 2005