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In vitro and animal model research has explored its interactions with corticotropin release, LH secretion, and somatostatin suppression

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In addition to stimulating adrenocorticotropic hormone (ACTH) release from the pituitary and the cascade of events leading to glucocorticoid release, CRH is also released into the arcuate nucleus of the hypothalamus (ARC) to inhibit neuropeptide Y (NPY)/agouti-related peptide (AGRP) neurons there (Richard et al., 2002)

[DOI] [PubMed] [Google Scholar] 160.Phan J., Calvo D.C., Nair D., Jain S., Montagne T., Dietsche S., Blanchard K., Treadwell S., Adams J., Krajmalnik-Brown R