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These include engineering T cells with enhanced expression of antiapoptotic factors such as Bcl-2 or Bcl-xL to confer resistance to AICD, pharmacological inhibition of ferroptosis using small molecules such as ferrostatin-1 or liproxstatin-1 to preserve T-cell viability under metabolic stress, and combination approaches that simultaneously target cell death pathways and immune checkpoint blockade to prolong T-cell survival and sustain antitumor responses [312]

Dosage Requirement Initial glutathione doses at Dermatonik Clinic range from 600 to 1200 mg weekly for 1-2 months, adjusted based on individual response and skin condition

Special thanks are also extended to the Comprehensive Research Laboratory and the Center for Breeding and Cultivation of Laboratory Animals at the Jiroft University of Medical Sciences for their invaluable resources and assistance throughout this research