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By means of processes like stimulating Treg cell proliferation and encouraging the transformation of M0-type macrophages into M2-type, IDO creates an immunosuppressive milieu in the TME that facilitates tumor evasion of immune surveillance ( IDO1 plays a key role in immune escape in AML, but targeted therapy is still in the early stage of exploration

But for a meaningful number of them, the full picture turns out to be more complicated than a single hormone in a syringe

It appears to be a powerful tissue defender and an anti-inflammatory drug that regulates the oxidative damage that happens following tissue injury

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