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They can promote mitochondrial biogenesis (increasing the number and function of mitochondria within cells), increase antioxidant activity, stabilize mitochondrial membranes, assist with ATP production, and modulate cell signaling and protection

Experimental investigations have examined its interactions with AR-mediated signaling pathways, receptor binding dynamics, transcriptional regulation mechanisms, and ligand-receptor interactions

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doi: 10.1016/s0196-9781(97)00128-9
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Systemic administration of IGF-I enhances healing in collagenous extracellular matrices: evaluation of loaded and unloaded ligaments
