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AP develops into systemic inflammation while local inflammation in the pancreas can develop into persistent systemic inflammatory response syndrome (SIRS) which can subsequently lead to multiple organ dysfunction syndrome (MODS) [1, 2]

Kishimoto T

(2012) 7:e49518

Glenn Laboratories for the Biology of Aging, the Kogod Center on Aging, and NIH National Institute on Aging grants AG26094, AG58812 and CA233790

M1 macrophages exhibit reduced susceptibility to RSL3-triggered ferroptosis because of the elevated levels of nitric oxide radicals, which inhibit lipid peroxidation

More interestingly, several studies support that ferroptosis and necroptosis are alternative pathways, such that resistance to one pathway sensitizes cells to death via the other pathway