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If triggers like sun exposure continue, skin may gradually return to its previous state, but niacinamide itself does not cause rebound darkening

doi: 10.1016/j.pnpbp.2013.09.017

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In addition, cysteine is the most nucleophilic amino acid of proteins and can react with endogenous or exogenous electrophiles which can result in the formation of covalent bonds, which can alter the cellular states and functions