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In fact, scurvy was the leading cause of naval deaths between the 16th and 18th centuries, killing more sailors than all battles, storms and other diseases combined

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Methodologically, 3-nitrotyrosine is a useful but not fully specific footprint (requires LC-MS validation and protein-level mapping) and boronate-based probes detect ONOOH and H 2 O 2 unless kinetic discrimination and scavenger controls are used (Benhar et al

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The major challenge is to balance activating CICD pathways without inducing harmful responses, such as inflammation, immune evasion, and therapy resistance (Zhao et al

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