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These changes were found not only in untreated individuals but also in those who were being treated with the medication quetiapine

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At the severe end of this spectrum, persistent energy deficiency may lead to functional hypothalamic amenorrhea (FHA), characterized by suppression of GnRH pulsatility and consequent disruption of ovulatory function, representing a reversible but clinically significant manifestation of energy-conserving neuroendocrine adaptation [90]

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Podiatrists widely use PRP for the treatment of plantar fasciitis, Achilles tendon, and ankle ligament injuries

This systemic effect simply cannot occur with topical application