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Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides

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Carcinogenesis 4, 1021029

This unique function allows tumor cells to more efficiently metabolize glucose, providing both energy and the molecular precursors for biomass synthesis (Table 1)

Its research value comes from observing changes across multiple readouts, including focal adhesion-associated signaling, paxillin-related adhesion remodeling, VEGFR2-axis endothelial responses, NO-related signaling, and tube-formation parameters

( Summary Glutathione biosynthesis plays a key role in maintaining redox balance and homeostasis in plants
