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High salt diet stimulates gut Th17 response and exacerbates TNBS-induced colitis in mice

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IL-1-induced increase in intestinal epithelial tight junction permeability is mediated by MEKK-1 activation of canonical NF-B pathway

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Rather than focusing on short-term anecdotes, serious investigators try to map which pathways appear most responsive, what concentrations are relevant in their models, and how repeatable those findings are in different systems