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Imaizumi VM, Laurindo LF, Manzan B, et al

While bivalent ligands have been shown to enhance binding affinity, rarely do additional pharmacophores beyond two result in further potency gains [205, 217]

53 Before ending this section, it should be noted that the downstream component of MAPK is ERK, and MMs bearing the BRAFV600E mutation are considered by some investigators to be driven by deregulated ERK signaling

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