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NICE doesnt recommend glucosamine or chondroitin: the evidence is inconsistent, and the larger trials have not shown benefit

Strengthen your nutrition foundation by prioritizing high-protein meals, which enhance satiety and preserve lean muscle during the transition

Histological endpoints Histological endpoints to assess response to a therapeutic intervention can be broadly divided into those meeting a numerical reduction in one of two accepted scoring systems: NAFLD Activity Score (NAS) or Steatosis Activity and Fibrosis (SAF) score or the resolution of NASH as determined by a qualified hepatopathologist.[35], [36] When change in the NAS is used as a primary outcome, it is recommended that 2 point improvement in total score be achieved with contribution from multiple parameters of the NAS, alongside no worsening of fibrosis.37 For trials evaluating resolution of NASH, this is defined as a complete resolution of hepatocyte ballooning, with inflammation scores of 0 or 1, in addition to no worsening of fibrosis, though there is no specific requirement regarding change in steatosis

Retatrutide is currently in Phase Three clinical trials

Acknowledgements We thank Dr Serge Luquet, Giuseppe Gangarossa, Nicolas Thiebaud and Claire Martin for their advice and helpful discussions

Diabetic retinopathy in people with diabetes In semaglutide studies in diabetes, early worsening of diabetic retinopathy complications was observed, likely related to rapid glucose improvement rather than a direct drug effect