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Conclusions Morning serum cortisol is negatively correlated with TIR, especially diurnal TIR and positively associated with GV parameters

Amylyx updates investors on its rare disease pipeline, including avexitides Phase 3 LUCIDITY trial, AMX0035 in Wolfram syndrome, AMX0114 in ALS, and a $317M cash position with runway into 2028 through potential avexitide approval and launch in 2027.
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However, the drugs alterations in gut motility may account for many of their commonly reported adverse effects including nausea, vomiting, early satiety, dyspepsia, and bowel habit changes
