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In addition, injection site side effects were reported for Bydureon including local inflammation, abscess formation and cosmetic concerns due to retention of bumps under the skin that remain for extended periods of time due to the long time required for polymer degradation [159]

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The anatomical and functional substrate of this neurovascular degeneration is the BBB, a dynamic and semi-permeable interface between blood and the central nervous system that has consistently been shown to be defective

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