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Adverse reactions were compared between combination therapy and monotherapy (GLP-1 RAs or metformin alone), followed by stratified analyses by gender, age, and body weight

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This approach highlights how nutritional substrates and metabolic cofactors may influence physiological resilience during sustained pharmacological weight reduction

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We propose that these changes in monotreme GLP-1 are the result of conflicting function of this peptide in metabolic control and venom

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