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For example, the glutathione disulfide (GSSG) reduction to glutathione (GSH) is driven by the NADPH generated during the first step of the PPP pathway, when glucose-6-phosphate is converted to 6-P-gluconate

Orlistat (Xenical, alli) does not affect heart rate as it works by blocking fat absorption in the gut rather than through systemic stimulation

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This triple mechanism appears to produce greater metabolic effects, particularly for weight reduction and liver fat content

Glucolipotoxicity-induced oxidative stress is related to mitochondrial dys-function and apoptosis of pancreatic -cell

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