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doi: 10.1016/S0140-6736(18)32261-X 15 GersteinHCColhounHMDagenaisGRDiazRLakshmananMPaisPet al

Conclusion In summary, GLP-1RAs have revolutionized obesity and diabetes management, offering potent weight loss and cardiometabolic benefits, but are best used in conjunction with lifestyle interventions, particularly exercise, to optimize health outcomes and sustainability

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Expanding applications: GLP-1s are now being explored beyond metabolic diseases, including liver disease (e.g., MASH/NAFLD), cardiovascular health, sleep apnea, alcohol use disorder, and potentially reducing obesity-related cancer risk