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Five clinical trials (SURPASS 1-5 trials) conducted in patients with T2DM showed that tirzepatide at 5-15 mg per week could reduce body weight (5.4-11.7kg), which was never seen with a single drug (129)

Conclusion The study found that GLP-1RA therapy is effective not only in managing blood glucose levels in individuals with type 2 diabetes but also in reducing body weight in obese individuals and changing unhealthy eating tendencies, such as the tendency to eat in response to external food cues (external eating)

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SURMOUNT-1: This study began in late 2019 and focused on adults with obesity or overweight who did not have diabetes

Just keep in mind that theres not a lot of research showing whether these supplements work in humans

Prescribers who have expertise in obesity medicine While any licensed physician can prescribe GLP-1s, the nuances of safe and effective treatment are best handled by specialists in obesity medicine, primary care, endocrinology, or related fields