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Semaglutide Summary Semaglutide is a relatively new drug that has been shown to be just as effective at reducing body weight as certain weight loss surgeries

-Glucosidase Inhibitors Examples: Acarbose, Miglitol Mechanism: Delay carbohydrate absorption in intestine postprandial hyperglycemia Side Effects: Flatulence, diarrhea, abdominal discomfort Weight: Neutral Summary by Main Effects Reduce insulin resistance: Metformin, TZDs Increase insulin secretion: Sulfonylureas, Meglitinides Enhance incretin effect: DPP-4 inhibitors, GLP-1 agonists Increase glucose excretion: SGLT-2 inhibitors Delay carb absorption: -glucosidase inhibitors Key Point: First-line drug: Metformin (unless contraindicated)

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Ozempics manufacturer Novo Nordisk also offers Wegovy (higher dose semaglutide) specifically for weight management, and Saxenda (liraglutide) for weight loss

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