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G1~qvA=C` 5 H
Nimptsch, K
T.TierneyE.DziuraJ.et al
Liver carboxyesterase Zwitter ionic Polar Easily excreted General notes regarding phase-I metabolism Esters that are sterically hindered are hydrolyzed more slowly and may be appeared unchanged in urine: General notes regarding phase-I metabolism Amides are more stable to hydrolysis than esters.large fraction of amide containing drugs are normally excreted unchanged
Loss of place specificity in hippocampal complex spike cells of senescent rat. Neurobiology of Aging
doi: 10.1186/1742-2094-9-112 68
