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(2004) In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase

Inactivation of the proteasome system in fibroblast cells is related to the generation of singlet oxygen, protein oxidation and transcriptional agents that regulate MMP-1 expression activation (31)

[DOI] [PMC free article] [PubMed] [Google Scholar] [58].Ishihara N, Nomura M, Jofuku A, Kato H, Suzuki SO, Masuda K, et al

doi: 10.1016/j.jand.2022.01.014 50

NSCLC cells are dependent on glutamine through the metabolic reprogramming caused by the mutation of oncogenes or tumor suppressor genes, which makes them unable to grow normally under glutamine deprivation

The ketone beta-hydroxybutyrate extends lifespan and improves cognition in yeast and fly models by directly inhibiting histone deacetylases as well as reducing ROS (Shimazu et al., 2013