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Moreover, our results highlight the essential role of vitamin B12 in homocysteine metabolism, as supplementation was associated with a significant reduction in serum homocysteine levelsan important biomarker associated with cardiovascular and neurodegenerative diseases
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More alarming, vitamin B12 deficiency was twice as common among those taking metformin

4 Therefore, it carries a Category 2 bulk drug substance restriction

Sublingual B12 performs better than pills but still has absorption limitations

P.BorgesB
